The computational chemistry and physics group and the analytical chemistry group, both at the Van ‘t Hoff Institute for Molecular Sciences in the Faculty of Science of the University of Amsterdam (UvA), are looking for a talented and dedicated researcher to join a challenging project on predicting the effect of ions on the multimerization properties of an industrially relevant enzyme.
What are you going to do?
The project aims to understand the effect of ion type and concentration on the conformation and multimerization properties of beta-galactosidase, an industrially relevant enzyme. You will develop a molecular simulation protocol to compute the affinity of β-galactosidase for ions, which will be employed to predict the effects of ions on the dimerization and tetramerization properties of β-galactosidase. The predictions will be tested by AF4-MALS experiments.