Rational design of ligands to optimize the cellular uptake of nanoparticles

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Ioana M. ILIE

Ioana M. ILIE

Rational design of ligands to optimize the cellular uptake of nanoparticles

Project type and duration:

6-9 months

Supervisors:

Ioana M. ILIE

Group:

Computational Chemistry

Institute:

van 't Hoff Institute for Molecular Sciences

Project description

Nanoparticles (NPs) are used to efficiently deliver drugs into diseased cells. They are engineered from rigid or soft platforms of various shapes and sizes, and decorated with ligands to improve water solubility, avoid aggregation and ensure cell-targeting specificity. This aim of this project is to rationally design ligands for metal nanoparticles, probe their specificity via computer simulations and validate them in an experimental setup. This project is meant for students who have both a theoretical and an experimental interest. The experimental research will be carried out in the group of Prof. Hong Zhang at HIMS.

Interested? please apply here

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November 12, 2020 No Comments